Yes, CB AntiSpam can have preconfigured block rules to block logins, registrations, and more. You can block ip addresses, ip ranges, email addresses, and email domains. It supports partial matching as well.

What issues are you having with creating blocks? Navigate to CB > Plugin Management and click Blocks under the CB AntiSpam plugin. From there you should be on the blocks page. Now click New on the top toolbar to create a new block. To block an email domain set Type to Email Domain and supply the domain to Value then adjust when you want the block to affect and for how long.

Another option is to edit the email field within CB > Field Management then add a comma list of domains to "Registration Forbidden Words" and "Profile Edit Forbidden Words" under Parameters > Validation to use validation to block domains from being used in that email field.

Is it possible to enter a whole blacklist, or mantain one somehow?

No, you'd have to create a block for each domain. Have added a feature ticket to look into supporting blocklists in a single block configuration.

forge.joomlapolis.com/issues/7947

Also, integratig with some servi like this may be useful:

There are no plans to implement external blocking services at this time. We can't really verify what those external services would do with everyone's information as typically you're giving them someones email address to verify and could be of massive privacy concerns.