3. When I go into the User List for modification, I tab until I get to Usergroups. It tells me there is a edit box and then it gives me the list box and just starts reading the entire list of contents. Then you tab again and you occasionally get another list where it just says blank.

When you first tab to the field it's reading back to you what is already selected, but since you've 84 selected that might take awhile. It'll always say the blank because of the search input, but that's fine to ignore.

I cannot even make any selections or remove groups that were previously added.

Press Enter once you've focused the element then navigate with arrow keys and press enter to make selections. This is the same process you'd use for a single select except you can select more than 1 option.

Ensure CB it self is completely up to date. To rule out browser cache (which shouldn't be a problem, but you never know) press ctrl + f5 to refresh the page without cache. Then retry. I'm testing with NVDA 2018.2.1 and Chrome 67.0.3396.99. I'm not sure what more to suggest or do as everything is working fine in my tests. You can apply the change noted below to prevent select2 usage being used entirely and it'll just be a standard multiselect element again if it's still not working to your satisfaction.

www.joomlapolis.com/forum/153-professional-member-support/239452-7225-accessibility-issues-with-2-2-0-and-latest-joomla-release-for-administrators?start=12#306181

If other select elements are working fine except that one it may just have too many options to be accessible friendly and you may need to consider reducing the number of usergroups. The screen reader would have to read out a significant amount of options and multiselect accessibility isn't that great even with standard HTML elements and it absolutely is not an option to turn it into a massive multi checkbox field.

That change completely disables select2 usage in backend. There's not likely to be an option to do that. What you're using now is just standard browser select2. We've changed to SelectWoo, which is a fork of select2 to improve accessibility and seams to work fine in my tests so I'm unsure why it wasn't working fine for you. Will continue to investigate potential accessible issues with select2, but doesn't appear to be any serious problems reported below.

github.com/woocommerce/selectWoo/issues