I had the same problem. I tracked it down to two calls to update_checker(), one in admin.comprofiler.html.php; the other in comprofiler.class.php. Commenting these two calls allowed my test instance to work.
My test instance is located behind a corporate firewall. I noticed a long time elapsed between clicking on the Config Mgr link and the display of the Config Mgr icon. Now it makes sense that something was timing-out and the code wasn't catching the failure.
Question for developers: Is it really necessary to check for updates with every single action?